Introduction

Senior Discovery Scientist (Contract)

Toronto, ON

What are you going to do

Responsibilities

Develop and perform biochemical and/or cell-based assays to characterize the activity of early-stage ligands, such as ELISAs, cytotoxicity assays, or fluorogenic reporter assays.
Passage and prepare mammalian cells to be used in assays.
Develop methods to assess compound affinity, retention, and internalization of compounds.
Support the generation of in vitro assay data for established projects.
Interface with external vendors to support early discovery activities.
Critically assess data and methods, adapting and adjusting procedures as necessary.
In conjunction with managers, establish priorities and meet timelines for key experiments.
Provide clear communication of scientific data to co-workers through internal presentations and written methods.
Support preclinical and late-stage assets as necessary.

Essential skills and knowledge

Requirements

M.Sc or Ph.D. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline with 3+ years relevant postgraduate experience (industry preferred)
Demonstrated success independently designing experiments and planning scientific projects.
Experience with mammalian cell culture and aseptic techniques.
Strong background in the development and optimization of cell-based reporter assays and cytotoxicity assays.
Experience performing in vitro biochemical/biophysical assays.
Familiarity with confocal microscopy, immunofluorescence and imaging of live/fixed cells.
Ability to communicate scientific data effectively to an interdisciplinary team.
Excellent problem-solving and decision-making skills.
Working knowledge of MS Office, Graphpad Prism, and ChemDraw.
Experience with radiobinding assays or handling of radioactive materials is an asset.
Experience with protein purification and analysis methods is an asset.
Travel for team and client meetings required.

What we offer

What We Offer

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